When asked what’s so special about Drosophila melanogaster, or the common fruit fly, Gerry Rubin quickly gets on a roll. Rubin has poked and prodded flies for decades, including as a leader of the effort to sequence their genome. So permit him to count their merits. They’re expert navigators, for one, zipping around without crashing into walls. They have great memories too, he adds. Deprived of their senses, they can find their way around a room—much as you, if you were suddenly blindfolded, could probably escape through whichever door you most recently entered.