The story of Venky Mama is simple and straightforward one punctuated by an ‘astrology’ twist. The less said about it, the better as that would be akin to revealing everything the film has to offer story-wise. Read below, if you still want to know about it, but be warned about the spoilers. Rama Narayana (Nassar) is a respected head in the village, who also is a great astrologer. He believes in destiny. According to him, his grandson Karthik (Naga Chaitanya), will bring death to their parents within one year. With no parents, Uncle Ratnam takes care of Karthik from childhood as a father. However, all of a sudden Karthik leaves Venkat Ratnam? Why did he leave? What does Rama Narayana fear is what the movie is all about?